Dosing and administration of MONJUVI + lenalidomide

  • MONJUVI should be administered by a healthcare professional with immediate access to emergency equipment and appropriate medical support to manage IRRs1
  • The recommended dose of MONJUVI is 12 mg/kg based on actual body weight administered as an intravenous infusion according to the dosing schedule in the table below1
  • Administer MONJUVI in combination with lenalidomide 25 mg orally on days 1 to 21 of each 28-day cycle for a maximum of 12 cycles, then continue MONJUVI as monotherapy until disease progression or unacceptable toxicity1
  • Refer to the lenalidomide prescribing information for lenalidomide dosage recommendations1
  • Administer MONJUVI as an intravenous infusion1
    1. For the first infusion, use an infusion rate of 70 mL/h for the first 30 minutes; then, increase the rate so that the infusion is administered within 1.5 to 2.5 hours1
      1. In the L-MIND study, after the first 30 minutes, the rate of infusion was increased to 125 mL/h over a 2-hour period2
    2. Administer all subsequent infusions within 1.5 to 2 hours1
    3. In the L-MIND study, vital signs were measured immediately prior to infusion, at 15 minutes (+/- 5 minutes), 30 minutes (+/- 10 minutes), every 60 minutes (+/- 15 minutes), and at the end of the infusion (+/- 20 minutes)2

See Recommended Premedications for more information about MONJUVI premedications.

The cycle length for MONJUVI is 28 days1
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Cycle 1
DAYS12345678910111213141516171819202122232425262728
MONJUVI 12 mg/kg■  ■   ■      ■      ■      
Lenalidomide 25 mg daily●●●●●●●●●●●●●●●●●●●●●       
Cycles 2 and 3
DAYS12345678910111213141516171819202122232425262728
MONJUVI 12 mg/kg■      ■      ■      ■      
Lenalidomide 25 mg daily●●●●●●●●●●●●●●●●●●●●●       
Cycles 4 to 12
DAYS12345678910111213141516171819202122232425262728
MONJUVI 12 mg/kg■             ■             
Lenalidomide 25 mg daily●●●●●●●●●●●●●●●●●●●●●       
After 12 cycles, continue MONJUVI monotherapy until disease progression or unacceptable toxicity
 
DAYS12345678910111213141516171819202122232425262728
MONJUVI 12 mg/kg■             ■             
 
Cycle 1
MONJUVI 12 mg/kg on days 1, 4*, 8, 15, 22
Lenalidomide 25 mg daily by mouth on days 1 to 21
*Loading dose on day 4 is given in cycle 1 only.
 
Cycles 2 and 3
MONJUVI 12 mg/kg on days 1, 8, 15, 22
Lenalidomide 25 mg daily by mouth on days 1 to 21
 
Cycles 4 to 12
MONJUVI 12 mg/kg on days 1, 15
Lenalidomide 25 mg daily by mouth on days 1 to 21
 
After 12 cycles, continue MONJUVI monotherapy until disease progression or unacceptable toxicity
MONJUVI 12 mg/kg on days 1, 15

Download the Management Guide

Provides a comprehensive overview of MONJUVI to help healthcare professionals manage treatment.