Dosing & Administration

Dosing and administration of MONJUVI + lenalidomide

• MONJUVI should be administered by a healthcare professional with immediate access to emergency equipment and appropriate medical support to manage IRRs¹
• The recommended dose of MONJUVI is 12 mg/kg based on actual body weight administered as an intravenous infusion according to the dosing schedule in the table below¹
• Administer MONJUVI in combination with lenalidomide 25 mg orally on days 1 to 21 of each 28-day cycle for a maximum of 12 cycles, then continue MONJUVI as monotherapy until disease progression or unacceptable toxicity¹
• Refer to the lenalidomide prescribing information for lenalidomide dosage recommendations¹
• Administer MONJUVI as an intravenous infusion¹
  1. For the first infusion, use an infusion rate of 70 mL/h for the first 30 minutes; then, increase the rate so that the infusion is administered within 1.5 to 2.5 hours¹
     1. In the L-MIND study, after the first 30 minutes, the rate of infusion was increased to 125 mL/h over a 2-hour period²
  2. Administer all subsequent infusions within 1.5 to 2 hours¹
  3. In the L-MIND study, vital signs were measured immediately prior to infusion, at 15 minutes (+/- 5 minutes), 30 minutes (+/- 10 minutes), every 60 minutes (+/- 15 minutes), and at the end of the infusion (+/- 20 minutes)²

See Recommended Premedications for more information about MONJUVI premedications.